2024

Effects of Centrally Acting Analgesics on Resting-State Electroencephalography Biomarker Candidates of Chronic Pain. OPEN ACCESS

Zebhauser PT, Bott FS, Gil Ávila C, Heitmann H, May ES, Tiemann L, Baki E, Tölle TR, Ploner M.

bioRxiv 2024.06.23.600313; doi: https://doi.org/10.1101/2024.06.23.600313

Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEG. OPEN ACCESS

Gil Avila C, May ES, Bott FS, Tiemann L, Hohn VD, Heitmann H, Zebhauser PT, Gross J, Ploner M.

bioRxiv 2024.07.23.604775; doi: https://doi.org/10.1101/2024.07.23.604775

Assessing the predictive value of peak alpha frequency for the sensitivity to pain. OPEN ACCESS

May ES, Tiemann L, Gil Ávila C, Bott FS, Hohn VD, Gross J, Ploner M.

bioRxiv 2024.06.27.600974; doi: https://doi.org/10.1101/2024.06.27.600974

Developing neuroimaging-based biomarkers of pain: systematic and coordinated approaches. 

Ploner M.

Pain. 2024. doi: 10.1097/j.pain.0000000000003393.

Resting-State Electroencephalography and Magnetoencephalography in Migraine - A Systematic Review and Meta-Analysis. OPEN ACCESS

Zebhauser PT, Heitmann H, May ES, Ploner M.

J Headache Pain. 2024. 25: 147. DOI: https://doi.org/10.1186/s10194-024-01857-5.

ENIGMA-Chronic Pain. a worldwide initiative to identify brain correlates of chronic pain. OPEN ACCESS

Quide Y, Jahanshad N, Andoh J, Antoniou G, Apkarian AV, Ashar YK, Badran BW, Baird CL, Baxter L, Bell TR, Blanco-Hinojo L, Borckardt J, Cheung CL, Ciampi de Andrade D, Couto BA, Cox SR, Cruz-Almeida Y, Dannlowski U, De Martino E, de Tommaso M, Deus J, Domin M, Egorova-Brumley N, Elliott J, Fanton S, Fauchon C, Flor H, Franz CE, Gatt JM, Gerdhem P, Gilman JM, Gollub RL, Govind V, Graven-Nielsen T, Hakansson G, Hales T, Haswell C, Heukamp NJ, Hu L, Huang L, Hussain A, Jensen K, Kircher T, Kremen WS, Leehr EJ, Lindquist M, Loggia ML, Lotze M, Martucci KT, Meeker TJ, Meinert S, Millard SK, Morey RA, Murillo C, Nees F, Nenadic I, Park HRP, Peng X, Ploner M, Pujol J, Robayo LE, Salan T, Seminowicz DA, Serian A, Slater R, Stein F, Stevens J, Strauss S, Sun D, Vachon-Presseau E, Valdes-Hernandez PA, Vanneste S, Vernon M, Verriotis M, Wager TD, Widerstrom-Noga E, Woodbury A, Zeidan F, Bhatt RR, Ching CRK, Haddad E, Thomopoulos SI, Thompson PM, Gustin SM.

Pain. 2024. doi: 10.1097/j.pain.0000000000003317.

2023

DISCOVER-EEG: an open, fully automated EEG pipeline for biomarker discovery in clinical neurosciences. OPEN ACCESS

Gil Avila C, Bott FS, Tiemann L, Hohn VD, May ES, Nickel MM, Zebhauser PT, Gross J, Ploner M

Sci Data. 2023. 10: 613. doi: 10.1038/s41597-023-02525-0.

Resting-state EEG and MEG biomarkers of pathological fatigue - A transdiagnostic systematic review. OPEN ACCESS

Heitmann H, Zebhauser PT, Hohn VD, Henningsen H, Ploner M

Neuroimage Clin. 2023. 39: 103500. doi: 10.1016/j.nicl.2023.103500.

Next steps for global collaboration to minimize racial and ethnic bias in neuroscience. 

Müller R, Ruess AK, Scönweitz FB, Buyx A, Gil Ávila C, Ploner M

Nat Neurosci. 2023. 26:1122-1123. doi: 10.1038/s41593-023-01369-6.

Local brain oscillations and interregional connectivity differentially serve sensory and expectation effects on pain. OPEN ACCESS

Bott FS, Nickel MM, Hohn VD, May ES, Gil Avila C, Tiemann L, Gross J, Ploner M

Sci Adv. 2023. 9:eadd7572. doi: 10.1126/sciadv.add7572.

Reengineering neurotechnology: placing patients first.

Ploner M, Buyx A, Gempt J, Gjorgijeva J, Müller R, Priller J, Rückert D, Wolfrum B, Jacob S 

Nat Ment Health. 2023. 1:5-7. doi: 10.1038/s44220-022-00011-x.

Resting state EEG and MEG as biomarkers of chronic pain: a systematic review. OPEN ACCESS

Zebhauser PT, Hohn VD, Ploner M.

Pain. 2023. 164:1200-1221. doi: 10.1097/j.pain.0000000000002825.

2022

How do alpha oscillations shape the perception of pain? - An EEG-based neurofeedback study. OPEN ACCESS

Hohn VD, Bott FS, May ES, Tiemann L, Fritzen C, Nickel MM, Gil Ávila C, Ploner M

PLoS Biol, Registered Report, in-principle accepted. 2022. doi: 10.17605/OSF.IO/QBKJ2.

Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity.  OPEN ACCESS

Bingel U*, Wiech K*, Ritter C, Wanigasekera V, Ní Mhuircheartaigh R, Lee MC, Ploner M, Tracey I

Eur J Neurosci. 2022. 56:3967-3978. doi: 10.1111/ejn.15687. 

*equal contribution

Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: a transdiagnostic multimodal meta-analysis of structural and functional MRI studies. OPEN ACCESS

Brandl F, Weise B, Mulej Bratec S, Jassim N, Hoffmann Ayala D, Bertram T, Ploner M, Sorg C

Neuropsychopharmacology. 2022. 47:1071-1080. doi: 10.1038/s41386-022-01271-y.

Longitudinal resting-state electroencephalography in patients with chronic pain undergoing interdisciplinary multimodal pain therapy. OPEN ACCESS

Heitmann H, Gil Ávila C, Nickel MM, Ta Dinh S, May ES, Tiemann L, Hohn VD, Tölle TR, Ploner M. 

Pain. 2022. 63:e997-e1005. doi: 10.1097/j.pain.0000000000002565.

Temporal-spectral signaling of sensory information and expectations in the cerebral processing of pain.      OPEN ACCESS

Nickel MM, Tiemann L, Hohn VD, May ES, Gil Avila C, Eippert F, Ploner M.

Proc Natl Acad Sci USA. 2022. 119:e2116616119. doi: 10.1073/pnas.2116616119.

2021

2019

Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography. OPEN ACCESS

Ta Dinh S, Nickel MM, Tiemann L, May ES, Heitmann H, Hohn VD, Edenharter G, Utpadel-Fischler D, Tölle TR, Sauseng P, Gross J, Ploner M.

Pain. 2019; 160(12):2751-2765. doi: 10.1097/j.pain.0000000000001666. 

Perceptual and motor responses directly and indirectly mediate the effects of noxious stimuli on autonomic responses. 

Tiemann L, Hohn VD, Ta Dinh S, May ES, Nickel MM, Heitmann H, Ploner M.

Pain. 2019; 160(12):2811-2818. doi: 10.1097/j.pain.0000000000001661. 

From correlations to causality: modulating brain rhythms of pain using transcranial alternating current stimulation. OPEN ACCESS

Hohn VD, May ES, Ploner M.

Pain Rep. 2019; 4(4):e723. doi: 10.1097/PR9.0000000000000723. 

Gamma oscillations shape pain in animals and humans.

Ploner M, Gross J.

Trends Cogn Sci. 2019; 23(6):450-1. doi: 10.1016/J.TICS.2019.04.001. 

Prefrontal gamma oscillations reflect ongoing pain intensity in chronic back pain patients. OPEN ACCESS

May ES, Nickel MM, Ta Dinh S, Tiemann L, Heitmann H, Voth I, Tölle TR, Gross J, Ploner M.

Hum Brain Mapp. 2019 Jan;40(1):293-305. doi: 10.1002/hbm.24373. 

2018

Motor Responses to Noxious Stimuli Shape Pain Perception in Chronic Pain Patients. OPEN ACCESS

Heitmann H*, May ES*, Tiemann L, Schmidt P, Nickel MM, Ta Dinh S, Hohn VD, Tölle TR, Ploner M.

eNeuro. 2018 Nov 29;5(5). pii: ENEURO.0290-18.2018. doi: 10.1523/ENEURO.0290-18.2018.

*equal contribution

Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli. OPEN ACCESS

Tiemann L, Hohn VD, Ta Dinh S, May ES, Nickel MM, Gross J, Ploner M.

Nat Commun. 2018 Oct 26;9(1):4487. doi: 10.1038/s41467-018-06875-x. 

Electroencephalography and magnetoencephalography in pain research - current state and future perspectives.

Ploner M, May ES.

Pain. 2018 Feb;159(2):206-211. doi: 10.1097/j.pain.0000000000001087. 

2017

Autonomic responses to tonic pain are more closely related to stimulus intensity than to pain intensity.

Nickel MM, May ES, Tiemann L, Postorino M, Ta Dinh S, Ploner M.

Pain. 2017 Nov;158(11):2129-2136. doi: 10.1097/j.pain.0000000000001010. 

Influence of pain on motor preparation in the human brain. OPEN ACCESS

Postorino M, May ES, Nickel MM, Tiemann L, Ploner M.

J Neurophysiol. 2017 Oct 1;118(4):2267-2274. doi: 10.1152/jn.00489.2017. 

Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations. OPEN ACCESS

Davis KD, Flor H, Greely HT, Iannetti GD, Mackey S, Ploner M, Pustilnik A, Tracey I, Treede RD, Wager TD.

Nat Rev Neurol. 2017 Oct;13(10):624-638. doi: 10.1038/nrneurol.2017.122. 

The effects of treatment failure generalize across different routes of drug administration.

Zunhammer M, Ploner M, Engelbrecht C, Bock J, Kessner SS, Bingel U.

Sci Transl Med. 2017 Jun 7;9(393). pii: eaal2999. doi: 10.1126/scitranslmed.aal2999. 

Behavioral responses to noxious stimuli shape the perception of pain. OPEN ACCESS

May ES, Tiemann L, Schmidt P, Nickel MM, Wiedemann N, Dresel C, Sorg C, Ploner M.

Sci Rep. 2017 Mar 9;7:44083. doi: 10.1038/srep44083. 

Brain oscillations differentially encode noxious stimulus intensity and pain intensity. OPEN ACCESS

Nickel MM, May ES, Tiemann L, Schmidt P, Postorino M, Ta Dinh S, Gross J, Ploner M.

Neuroimage. 2017 Mar 1;148:141-147. doi: 10.1016/j.neuroimage.2017.01.011. 

Brain Rhythms of Pain. OPEN ACCESS

Ploner M, Sorg C, Gross J. 

Trends Cogn Sci. 2017 Feb;21(2):100-110. doi: 10.1016/j.tics.2016.12.001. 

2016

Prevalence of neuropathic pain in early multiple sclerosis.

Heitmann H, Biberacher V, Tiemann L, Buck D, Loleit V, Selter RC, Knier B, Tölle TR, Mühlau M, Berthele A, Hemmer B, Ploner M.

Mult Scler. 2016 Aug;22(9):1224-30. doi: 10.1177/1352458515613643. 

Spontaneous Cerebrospinal Fluid Leak With Venous Engorgement Mimicking a Contrast-Enhancing Cervical Mass.

Herwerth M, Prothmann S, Kreiser K, Hemmer B, Ploner M.

JAMA Neurol. 2016 Jul 1;73(7):886-7. doi: 10.1001/jamaneurol.2016.0277. 

Metabolic connectivity mapping reveals effective connectivity in the resting human brain.

Riedl V, Utz L, Castrillón G, Grimmer T, Rauschecker JP, Ploner M, Friston KJ, Drzezga A, Sorg C.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):428-33. doi: 10.1073/pnas.1513752113. 

2015

Prefrontal Gamma Oscillations Encode Tonic Pain in Humans.

Schulz E, May ES, Postorino M, Tiemann L, Nickel MM, Witkovsky V, Schmidt P, Gross J, Ploner M.

Cereb Cortex. 2015 Nov;25(11):4407-14. doi: 10.1093/cercor/bhv043. 

Frontostriatal Gating of Tinnitus and Chronic Pain.

Rauschecker JP, May ES, Maudoux A, Ploner M.

Trends Cogn Sci. 2015 Oct;19(10):567-578. doi: 10.1016/j.tics.2015.08.002. 

Extensive Recruitment of Plasma Blasts to the Cerebrospinal Fluid in Toscana Virus Encephalitis.

Schirmer L, Wölfel S, Georgi E, Ploner M, Bauer B, Hemmer B.

Open Forum Infect Dis. 2015 Sep 1;2(3):ofv124. doi: 10.1093/ofid/ofv124.

Towards a taxonomy of pain modulations.

Ploner M, Bingel U, Wiech K.

Trends Cogn Sci. 2015 Apr;19(4):180-2. doi: 10.1016/j.tics.2015.02.007. 

Differential neurophysiological correlates of bottom-up and top-down modulations of pain.

Tiemann L, May ES, Postorino M, Schulz E, Nickel MM, Bingel U, Ploner M.

Pain. 2015 Feb;156(2):289-96. doi: 10.1097/01.j.pain.0000460309.94442.44. 

2014

Dissociable neural mechanisms underlying the modulation of pain and anxiety? An FMRI pilot study.

Wiech K, Edwards R, Moseley GL, Berna C, Ploner M, Tracey I.

PLoS One. 2014 Dec 15;9(12):e110654. doi: 10.1371/journal.pone.0110654. 

The effect of treatment history on therapeutic outcome: psychological and neurobiological underpinnings.

Kessner S, Forkmann K, Ritter C, Wiech K, Ploner M, Bingel U.

PLoS One. 2014 Oct 2;9(9):e109014. doi: 10.1371/journal.pone.0109014. 

Dopamine precursor depletion influences pain affect rather than pain sensation.

Tiemann L, Heitmann H, Schulz E, Baumkötter J, Ploner M.

PLoS One. 2014 Apr 23;9(4):e96167. doi: 10.1371/journal.pone.0096167. 

2013

The effect of treatment history on therapeutic outcome: an experimental approach.

Kessner S, Wiech K, Forkmann K, Ploner M, Bingel U.

JAMA Intern Med. 2013 Aug 12;173(15):1468-9. doi: 10.1001/jamainternmed.2013.6705. 

Amygdala activity contributes to the dissociative effect of cannabis on pain perception.

Lee MC, Ploner M, Wiech K, Bingel U, Wanigasekera V, Brooks J, Menon DK, Tracey I.

Pain. 2013 Jan;154(1):124-34. doi: 10.1016/j.pain.2012.09.017. 

2012

Decoding the perception of pain from fMRI using multivariate pattern analysis.

Brodersen KH, Wiech K, Lomakina EI, Lin CS, Buhmann JM, Bingel U, Ploner M, Stephan KE, Tracey I.

Neuroimage. 2012 Nov 15;63(3):1162-70. doi: 10.1016/j.neuroimage.2012.08.035. 

γ Oscillations are involved in the sensorimotor transformation of pain.

Schulz E, Tiemann L, Witkovsky V, Schmidt P, Ploner M.

J Neurophysiol. 2012 Aug;108(4):1025-31. doi: 10.1152/jn.00186.2012. 

Decoding an individual's sensitivity to pain from the multivariate analysis of EEG data.

Schulz E, Zherdin A, Tiemann L, Plant C, Ploner M.

Cereb Cortex. 2012 May;22(5):1118-23. doi: 10.1093/cercor/bhr186. 

Behavioral and neuronal investigations of hypervigilance in patients with fibromyalgia syndrome.

Tiemann L, Schulz E, Winkelmann A, Ronel J, Henningsen P, Ploner M.

PLoS One. 2012;7(4):e35068. doi: 10.1371/journal.pone.0035068. 

2011

Neurophysiological coding of traits and states in the perception of pain.

Schulz E, Tiemann L, Schuster T, Gross J, Ploner M.

Cereb Cortex. 2011 Oct;21(10):2408-14. doi: 10.1093/cercor/bhr027. 

Flexible cerebral connectivity patterns subserve contextual modulations of pain.

Ploner M, Lee MC, Wiech K, Bingel U, Tracey I.

Cereb Cortex. 2011 Mar;21(3):719-26. doi: 10.1093/cercor/bhq146. 

The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil.

Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, Tracey I.

Sci Transl Med. 2011 Feb 16;3(70):70ra14. doi: 10.1126/scitranslmed.3001244. 

Modulation of human time processing by subthalamic deep brain stimulation.

Wojtecki L, Elben S, Timmermann L, Reck C, Maarouf M, Jörgens S, Ploner M, Südmeyer M, Groiss SJ, Sturm V, Niedeggen M, Schnitzler A.

PLoS One. 2011;6(9):e24589. doi: 10.1371/journal.pone.0024589. 

2010

Differential effects of painful and non-painful stimulation on tactile processing in fibromyalgia syndrome and subjects with masochistic behaviour.

Pollok B, Krause V, Legrain V, Ploner M, Freynhagen R, Melchior I, Schnitzler A.

PLoS One. 2010 Dec 28;5(12):e15804. doi: 10.1371/journal.pone.0015804. 

Anterior insula integrates information about salience into perceptual decisions about pain.

Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I.

J Neurosci. 2010 Dec 1;30(48):16324-31. doi: 10.1523/JNEUROSCI.2087-10.2010. 

Gamma oscillations as a neuronal correlate of the attentional effects of pain.

Tiemann L, Schulz E, Gross J, Ploner M.

Pain. 2010 Aug;150(2):302-8. doi: 10.1016/j.pain.2010.05.014. 

Prestimulus functional connectivity determines pain perception in humans.

Ploner M, Lee MC, Wiech K, Bingel U, Tracey I.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):355-60. doi: 10.1073/pnas.0906186106. 

2009

Functional integration within the human pain system as revealed by Granger causality.

Ploner M, Schoffelen JM, Schnitzler A, Gross J.

Hum Brain Mapp. 2009 Dec;30(12):4025-32. doi: 10.1002/hbm.20826. 

Perceptual decisions: from sensory signals to behavior.

Gross J, Ploner M.

Curr Biol. 2009 Sep 29;19(18):R847-9. doi: 10.1016/j.cub.2009.07.023. 

2008

Neurocognitive aspects of pain perception.

Wiech K, Ploner M, Tracey I.

Trends Cogn Sci. 2008 Aug;12(8):306-13. doi: 10.1016/j.tics.2008.05.005. 

Impaired cerebral oscillatory processing in hepatic encephalopathy.

Timmermann L, Butz M, Gross J, Ploner M, Südmeyer M, Kircheis G, Häussinger D, Schnitzler A.

Clin Neurophysiol. 2008 Feb;119(2):265-72. 

Differential effects of levodopa and subthalamic nucleus deep brain stimulation on bradykinesia in Parkinson's disease.

Timmermann L, Braun M, Groiss S, Wojtecki L, Ostrowski S, Krause H, Pollok B, Südmeyer M, Ploner M, Gross J, Maarouf M, Voges J, Sturm V, Schnitzler A.

Mov Disord. 2008 Jan 30;23(2):218-27. 

2007

Evoked response amplitudes from somatosensory cortices do not determine reaction times to tactile stimuli.

Ploner M, Platzen J, Pollok B, Gross J, Schnitzler A.

Eur J Neurosci. 2007 Jun;25(12):3734-41. 

Gamma oscillations in human primary somatosensory cortex reflect pain perception.

Gross J, Schnitzler A, Timmermann L, Ploner M.

PLoS Biol. 2007 May;5(5):e133. 

2006

Wilson's disease tremor is associated with magnetic resonance imaging lesions in basal ganglia structures.

Südmeyer M, Saleh A, Wojtecki L, Cohnen M, Gross J, Ploner M, Hefter H, Timmermann L, Schnitzler A.

Mov Disord. 2006 Dec;21(12):2134-9. 

Acute axonal neuropathy and Wernicke's encephalopathy.

Lehmann HC, Lindenberg R, Arendt G, Ploner M.

J Neurol. 2006 Nov;253(11):1516-7. 

Pain processing is faster than tactile processing in the human brain.

Ploner M, Gross J, Timmermann L, Schnitzler A.

J Neurosci. 2006 Oct 18;26(42):10879-82. 

Oscillatory activity reflects the excitability of the human somatosensory system.

Ploner M, Gross J, Timmermann L, Pollok B, Schnitzler A.

Neuroimage. 2006 Sep;32(3):1231-6. 

Pain suppresses spontaneous brain rhythms.

Ploner M, Gross J, Timmermann L, Pollok B, Schnitzler A.

Cereb Cortex. 2006 Apr;16(4):537-40. 

2005

Herpes encephalitis after meningioma resection.

Ploner M, Turowski B, Wöbker G.

Neurology. 2005 Nov 22;65(10):1674-5. 

2004

[Cortical representation of pain].

Ploner M, Schnitzler A..

Nervenarzt. 2004 Oct;75(10):962-9. 

Pain facilitates tactile processing in human somatosensory cortices.

Ploner M, Pollok B, Schnitzler A.

J Neurophysiol. 2004 Sep;92(3):1825-9. 

2003

Wernicke's encephalopathy.

Ploner M, Schnitzler A.

Lancet. 2003 Mar 22;361(9362):1000. 

2002

Cortical representation of first and second pain sensation in humans.

Ploner M, Gross J, Timmermann L, Schnitzler A.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12444-8. 

Cortical representation of venous nociception in humans.

Ploner M, Holthusen H, Noetges P, Schnitzler A.

J Neurophysiol. 2002 Jul;88(1):300-5. 

2001

Differential coding of pain intensity in the human primary and secondary somatosensory cortex.

Timmermann L, Ploner M, Haucke K, Schmitz F, Baltissen R, Schnitzler A.

J Neurophysiol. 2001 Sep;86(3):1499-503. 

Behavioural relevance modulates access to spatial working memory in humans.

Ploner CJ, Ostendorf F, Brandt SA, Gaymard BM, Rivaud-Péchoux S, Ploner M, Villringer A, Pierrot-Deseilligny C.

Eur J Neurosci. 2001 Jan;13(2):357-63. 

2000

Neurophysiology and functional neuroanatomy of pain perception.

Schnitzler A, Ploner M.

J Clin Neurophysiol. 2000 Nov;17(6):592-603. 

Separate representations of static and dynamic touch in human somatosensory thalamus.

Timmermann L, Ploner M, Freund HJ, Schnitzler A.

Neurology. 2000 May 23;54(10):2024-6. 

Differential organization of touch and pain in human primary somatosensory cortex.

Ploner M, Schmitz F, Freund HJ, Schnitzler A.

J Neurophysiol. 2000 Mar;83(3):1770-6. 

1999

Parallel activation of primary and secondary somatosensory cortices in human pain processing.

Ploner M, Schmitz F, Freund HJ, Schnitzler A.

J Neurophysiol. 1999 Jun;81(6):3100-4. 

Pain affect without pain sensation in a patient with a postcentral lesion.

Ploner M, Freund HJ, Schnitzler A.

Pain. 1999 May;81(1-2):211-4.